Instantaneous antidepressant effect of lateral habenula deep brain stimulation in rats studied with functional MRI
The available treatments for depression have substantial limitations, including low response rates and substantial lag time before a response is achieved.We applied deep brain stimulation (DBS) to the lateral habenula (LHb) of two rat models of depression (Wistar Kyoto rats and lipopolysaccharide-treated rats) and observed an immediate (within seco